The Relationship between Mycoplasma Species and Selected Respiratory Viruses (Adenovirus, Influenza Virus and Rhinovirus)
Rept. no. 3 (Final) 1 Jan 1969-31 Dec 1971
PITTSBURGH UNIV PA DEPT OF MICROBIOLOGY
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The report describes the interaction of selected respiratory viruses and Eatons agent. For example, enhancement of rhinovirus-RNA synthesis in Mycoplasma pneumoniae treated KB cells was demonstrated, and in contrast the inhibition of poliovirus-RNA synthesis in similar treated cell systems. In addition, basic studies concerning the action of rhinovirus on cell systems are explained in terms of nucleotide phosphorylation and RNA incorporation of 3H- uridine. Because of the importance of other selected respiratory viruses adenovirus and influenza virus on the military population these agents were investigated. In particular, the effect of mycoplasma on adenovirus 3H- thymidine uptake and influenza virus infections of mice. For comparison with adenovirus-mycoplasma systems another DNA virus, herpes simplex virus, was employed.