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The Secretion of Pepsinogen and Amylase in Perspiration,

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Study of the secretions of ferments by the digestive glands as well as the incretions of enzymes has proved the gastric origin of pepsinogen and the mainly pancreatic origin of amylase secreted in urine. Their diagnostic value in cases of diseases of the stomach and pancreas in people not suffering from kidney disorders has also been established. The content of pepsinogen in sweat is much less than in urine. However, under conditions of profuse sweating, the loss of pepsinogen through the medium of sweat can teach significant proportions. In healthy people, the pepsinogen content of sweat fluctuates over wide limits, but amounts on average to 35.5 micrograms . Amylase occurs in human sweat in the same concentrations as in urine on the average 2.5 unitsml, but it fluctuates between wide limits from 0.5 to 8.7 unitsml. The pancreatic origin of amylase in sweat is substantiated by the fact that in sick people having chronic pancreatitis, an increase in the amylase content of sweat up to 58.1 and 80.1 unitsml respectively. A reverse relationship of the inverse type is observed between the secretions of amylase and pepsinogen in sweat if the pepsinogen content in the case of a non-complicated stomach ulcer was always high, then the content of amylase in sweat was low. Thus, the secretion of pepsinogen and amylase in sweat has its own peculiarities which depend on the functional condition of the stomach and pancreas, the kidneys and also on the condition of the secretion mechanism of the glands and their innervation.

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  • Anatomy and Physiology

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