Role of the Heart in Shock
OKLAHOMA UNIV MEDICAL CENTER OKLAHOMA CITY
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One of the perplexing problems of endotoxin shock pertains to the direct or indirect actions of endotoxin on the myocardium. It would be exceedingly important to clearly define the role of the heart in contributing to the development of systemic hypotension and inadequate blood flow in the early, intermediate and late phases of endotoxin shock. This manuscript summarizes research currently carried out in this laboratory on the role of the heart in shock. Five basic questions have been asked as follows 1 Is the heart poisoned directly by endotoxin 2 Does the heart perform an early role in the precipitation of irreversible endotoxin shock 3 Do circulating adrenergic agents mask circulating myocardial depressant factors in endotoxin shock 4 Are cardiodepressant substances circulating in the blood of animals shocked by endotoxin 5 Does the heart ultimately fail after endotoxin If so, what measurable parameters may be predictive of impending heart failure.
- Anatomy and Physiology
- Medicine and Medical Research