Accession Number:

AD0734655

Title:

Effect of Endotoxin on the S-A Node in situ in the Dog Heart

Descriptive Note:

Technical rept.

Corporate Author:

OKLAHOMA UNIV MEDICAL CENTER OKLAHOMA CITY

Personal Author(s):

Report Date:

1971-11-30

Pagination or Media Count:

8.0

Abstract:

Concentrations of endotoxin equivalent to those producing shock when given intravenously did not affect the S-A pacemaker activity of the dog in situ. Larger amounts of endotoxin, 100 micrograms to 1 mg, directly induced a negative chronotropic response, which was not blocked by atropine treatment. Endotoxin did not influence the effect of vagal stimulation and responses to acetylcholine and norepinephrine injected into the sinus node artery.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE