Autoregulation in Normal and Pathological States Including Shock and Ischemia.
OKLAHOMA UNIV MEDICAL CENTER OKLAHOMA CITY
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The purpose of this paper is to present findings from laboratory studies on the autoregulation mechanism of renal blood flow in the dog and its role in normal and pathological states in the canine and primate species. Partial and total renal artery occlusions of short and long durations and endotoxin shock were the stress conditions. Certain physical factors are thought to control or influence renal vascular resistance. Among these factors is intrarenal extravascular pressure. The phenomenon of autoregulation is durable, surviving two hours of total renal artery occlusion, although early postocclusion depression of autoregulation may be observed. It is seen to a limited extent in shock, although its usefulness to the organism may be limited by a variety of pathophysiological factors rendering it relatively inapplicable or ineffective. Author
- Anatomy and Physiology
- Medicine and Medical Research