The Influence of Postnecrotic Cirrhosis on Aflatoxin Carcinogenesis in Rats
NAVAL MEDICAL RESEARCH UNIT NO 2 MANILA (PHILIPPINES)
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Small doses of aflatoxins B1 and G1 administered by intraperitoneal injection to rats with CC14-induced postnecrotic cirrhosis rapidly cause hepatocellular carcinoma and advanced atypia of liver cells. Following administration of 600 G. of aflatoxins in three equal weekly doses to groups of animals with moderate to severe cirrhosis, 11 of 16 animals developed hepatoma within 12 weeks. When aflatoxins of the same dosage were administered to animals with fatty livers induced by ethanol, no hepatic tumor growths were found. Thirteen of 20 animals died within 37 weeks after administration of 1.6 mg. in eight equal weekly doses, including three with hepatocarcinoma and other with paranchymal liver necrosis andor pulmonary infection. Among the seven that survived, two developed liver cell cancer and two had a typical ductular hyperplasia. The data suggest that regenerative liver cells in cirrhotic nodules are more susceptible to environmental carcinogens such as aflatoxins.
- Medicine and Medical Research