Accession Number:

AD0734301

Title:

The Relationship between Hemoglobin Function and Membrane Integrity in Erythrocytes during Cold Storage.

Descriptive Note:

Interim rept.,

Corporate Author:

ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Report Date:

1971-09-21

Pagination or Media Count:

13.0

Abstract:

Whole human blood with and without the addition of adenine-inosine was stored for 42 days. Adenine-inosine was effective in maintaining hemoglobin function as shown by a continued high level of 2,3-DPG. Analysis of the erythrocyte membranes was carried out by chemical and physicochemical methods. It was shown that adenine-inosine treatment does not alter the rate of membrane deterioration, indicating that the maintenance of membrane integrity and hemoglobin function is a separate problem and each must be treated individually. The determining factor in long-term red cell preservation may well reside in membrane stabilization. Author

Subject Categories:

  • Medical Facilities, Equipment and Supplies

Distribution Statement:

APPROVED FOR PUBLIC RELEASE