Preparation and Research on Meningococcal Vaccines.
Rept. no. 3 (Annual) 6 Oct 70-31 Oct 71,
MERCK AND CO INC RAHWAY N J
Pagination or Media Count:
The preparation of approximately 20 gm. 413,350 x 50 mcg 0.5 ml doses of lyophilized meningococcal polysaccharide vaccine, type C, has been completed. The vaccine was produced in eight separate lots. Control testing of all eight lots has been completed - all lots met the specifications set forth in the contract. Three of the lots, which represent 156,300 x 50 mcg doses, already have been delivered to WRAIR. The preparation of approximately 5 gm. 100,000 x 50 mcg 0.5 ml doses of lyophilized meningococcal polysaccharide vaccine, type A, has been completed. The material was processed as two separate vaccine lots. Control testing of the materials presently is in progress. It has been observed that molecular weights decreased with the materials but were stabilized at a satisfactory level by storage at -20C. Pyrogen-free distilled water without preservative for restoration of all the vaccine has been prepared and is in the final stages of control testing. Author