Virus-Host Interactions in Abnormal Cells.
STATE UNIV COLL BROCKPORT N Y DEPT OF BIOLOGICAL SCIENCES
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Results of the investigation indicated that the infectivity titer of mouse hepatitis virus decreased after 6 hr incubation at 37C. Nutrient fluids from infected macrophage cultures retained pathogenicity in vivo and the ability to form polykaryons in vitro. Electron microscope studies of polykaryons formed from infected macrophage cultures showed the presence of virus-like particles in the cytoplasm. From the study, it was concluded that polykaryon formation in infected macrophage cultures resulted from an active viral agent. Author