A Concentration-Dependent Attenuation of Toxic Oxygen Effects in the Mouse.
ARIZONA STATE UNIV TEMPE
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Ninety male albino mice were exposed to 4, 6, or 8 atm oxygen partial pressure in 100, 50, or 25 dilutions. Tolerance was measured in terms of times to convulsion and times to death. Results indicated a both convulsion times and death times tended to increase with decreases in concentration, b the degree of change in tolerance as a function of concentration was greater for the low partial pressures, and c convulsion times and death times showed significant correlation only in the 4 atm partial pressure condition. The results further indicate a distinct decrease in susceptibility to toxic oxygen effects with increases in absolute pressure at fixed pO2. Author
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