Accession Number:

AD0733261

Title:

Synthesis of Infectious Ribonucleoprotein of Arbovirus in Subcellular Structures,

Descriptive Note:

Corporate Author:

FORT DETRICK FREDERICK MD

Report Date:

1971-12-03

Pagination or Media Count:

17.0

Abstract:

Mitochondrial-microsomal fraction isolated from chick fibroblasts infected with Venezuelan equine encephalomyelitis virus VEE and incubated in medium 199 insures extracellular synthesis of virus-specific RNA and proteins and formation of ribonuceloprotein complexes. These complexes possess infectivity which increases 80 to 100 times in 3-4 hours of incubation. The ribonucleoprotein complexes contain infectious RNA, which may be associated both with virus-specific and cellular proteins. The main part of the infectious RNA is formed extracellularly and not at the expense of the completion of templates derived from the cells along with the mitochondrial-microsomal fraction. Author

Subject Categories:

  • Biochemistry
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE