Oxime Acetates: Substrates for Acetylcholinesterase.
Technical rept. Jul 68-Feb 71,
EDGEWOOD ARSENAL MD
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Oxime acetates function as typical substrates for acetylcholinesterase AChE. Both syn 3- and syn 4-PAM acetates are rapidly hydrolyzed. Both are highly water soluble and give large changes in molar absorbance upon hydrolysis. Hence, they have potential utility for spectrophotometric studies with the enzyme. The prior configurational assignment of syn 4-PAMAc has been confirmed by nuclear magnetic resonance spectroscopy. Vicinal aliphatic dioxime diacetates are hydrolyzed by AChE, but quite slowly. Author