Development of a Long-Lasting Topical Lotion Effective in the Prevention of Cercaria Penetration of Human Skin.
Summary rept. no. 4 (Annual),
CREATIVE BIOLOGY LAB INC BARBERTON OHIO
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The purpose of this project is to develop a cosmetically acceptable topical film forming lotion that will prevent the penetration of schistosome cercaria. Candidate lotions were prepared based upon carboxylated polyacrylic film forming materials. By the addition of proper curatives and emoluents the applied lotion quickly dries to an integral film showing excellent dermal adhesion. Lotions were evaluated for cosmetic elegance and longevity. Superior candidates were applied to mice tails, allowed to dry and exposed to schistosome cercariae shed from infected snails. Experiments were performed wherein coated tails were exposed to water and abraded prior to exposure. Seven weeks after exposure subject and control mice were sacrificed. Worm burden was determined by visual observation of the liver, perfusion and maceration. Superior candidate formulations prevented cercariae penetration within the limits of the test performed. Human longevity of the films varies with environmental circumstances however, a 12 to 24 hour protection period is likely. Author