Response of 'Lipoprotein lipase' in Various Tissues to Cold Exposure.
DEFENCE AND CIVIL INST OF ENVIRONMENTAL MEDICINE DOWNSVIEW (ONTARIO)
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The response of lipoprotein lipase LPL activity in rat epididymal fat, brown fat, heart, lung, liver, and postheparin plasma to cold exposure 4 C for 1 and 28 days cold acclimated was examined. Whereas epididymal fat activity was markedly depressed -85 after only 1 day at 4C, large elevations in activity were found in brown fat 900, heart 120, lung 94, and postheparin plasma 50. These reciprocal changes persisted throughout acclimation. Liver showed no change. The findings suggest that the distribution between, and uptake of serum triglycerides by, extrahepatic tissues via LPL is altered by cold exposure to favor utilization and suppress deposition in the fat depots. Plasma insulin levels appear to be an important factor in the regulation of LPL activity in various tissues. Author
- Stress Physiology