Hereditary Persistence of Foetal Haemoglobin in Members of Two Chinese Families in Taiwan
NAVAL MEDICAL RESEARCH UNIT NO 2 MANILA (PHILIPPINES)
Pagination or Media Count:
Hereditary persistence of foetal haemoglobin HPFH has been found in Chinese subject from two families in Taiwan. The percentages of foetal haemoglobin as determined by an alkali denaturation test in the three subjects from one family were 16, 17, and 18. The single male subject from the second family had 19 per cent foetal haemoglobin. In addition to elevated foetal haemoglobin the subjects had the foetal haemoglobin distributed in all erythrocytes in a manner characteristic of HPFH and distinctly different from the distribution seen in Thalassaemia. All of the subjects were asymptomatic and refused to cooperate in further haematological studies. The foetal Haemoglobins from the HPFH subjects had electrophoretic mobilities identical to that of foetal haemoglobin from cord blood when examined by standard electrophoresis procedures on cellulose acetate, agar, and starch gel. The identification was verified in two unrelated subjects with HPFH by peptide mapping of the tryptic digest of their foetal haemoglobin fractions. The maps showed identical patterns for the F haemoglobin from the subjects and from cord blood haemoglobin. From present information the incidence of heterozygotes for HPFH among Chinese residents of Taiwan is estimated to be approximately one per 40, 000.
- Anatomy and Physiology