Accession Number:

AD0731124

Title:

The Effect of Cortisol upon Lipolysis during Hypercapnia and After Beta-Adrenergic Blockade.

Descriptive Note:

Final rept. Mar 67-Dec 68,

Corporate Author:

SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s):

• Pepelko,William E.

Report Date:

1971-05-01

Pagination or Media Count:

15.0

Abstract:

Injection of 6 mg.kg. cortisol I.V. into anesthetized eucapnic dogs resulted in a significant increase in plasma free fatty acid FFA levels, while noninjected controls showed no significant change in FFA levels. Beta-adrenergic blocking agents propranolol and KO 592 caused a rapid return of plasma FFAs to control levels in the dogs pretreated with cortisol. Cortisol neither stimulated lipolysis during acute hypercapnia, nor synergized with the lipolytic effects of norepinephrine during acute hypercapnia. The evidence suggests that the lipolytic effect of cortisol is not mediated by inhibition of cyclic AMP breakdown. Author

Descriptors:

• *CORTICOSTEROID AGENTS
• *FATTY ACIDS
• PHYSIOLOGY
• CARBON DIOXIDE
• BLOOD
• NOREPINEPHRINE
• METABOLISM
• ADENOSINE PHOSPHATES

Subject Categories:

• Anatomy and Physiology
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE