Personality and Reactivity to Tranquilizers.
Technical rept. 1965-1971,
EDGEWOOD ARSENAL MD
Pagination or Media Count:
The paper reports on the reactivity of non-patient male volunteers to four types of tranquilizers. The correlations between their performances and the Minnesota Multiphasic Personality Inventory MMPI scale scores and the General Intelligence Test GT score of the Army Classification Battery were studied. Subjects who had two or more MMPI standard scale scores above 70 were labeled abnormal. and those who did not were labeled normal. Significant correlations were found, depending on the population sampled and the type and dose of the drugs studied. Normal subjects had similar correlations between performance and personality measures after receiving secobarbital sodium 200 mg po and chlorpromazine hydrochloride 50 mg im. Normal subjects who received diazepam 10mg iv and a butyrophenone iv had similar correlations between performance and personality measures, but these correlations were distinct from those found with secobarbital sodium and chlorpromazine hydrochloride. Abnormal subjects tended to be more resistant to performance decrement than normal subjects to the doses of secobarbital sodium and chlorpromazine hydrochloride, but they were significantly more sensitive than normals to decrement in performance following diazepam 10 mg iv and amobarbital sodium 250 mg iv. Author