Duration of Resistance to Viral Infection Following Administration of Interferon Inducers
Final rept. Jun 1969-Jan 1970
SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TX
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The duration of protection afforded by 5 known interferon inducers was determined. Groups of mice were given a single dose of statolon, maleic acid-divinyl-ether copolymer pyran, polycytidylicpolyinosinic acid IC, Newcastle disease virus NDV, or bacterial endotoxin. These groups and an untreated control group were uniformly challenged with MM virus. Survival data obtained during 20 days after infection revealed that the duration of protection varied with the inducer. The longest periods of significant protection elicited by the inducers were endotoxin, 5 days NDV, 8 days IC, 30 days statolon or pyran, 55 days. These findings show that with the dosage used, the longest lasting protection was afforded by statolon and pyran.
- Medicine and Medical Research