Caffeine Potentiation of the Lethal Action of Alkylating Agents on L-Cells,
UNIVERSITY OF WESTERN ONTARIO LONDON CANCER RESEARCH LAB
Pagination or Media Count:
Studies of the mechanisms used by mammalian cells to repair DNA following UV irradiation are hampered by a lack of established cell lines which show differences in radiation sensitivity. The effect of caffeine on UV-treated mouse L-cells was studied. Caffeine strongly potentiated the lethal action of UV and the kinetics of the effect suggested that a repair process was being inhibited. Similar findings and conclusions were recently reported for caffeine and the alkylating agent mitomycin C. The present report discusses the list of alkylating agents whose action on L-cells is potentiated by caffeine.