Cyclonerodiol, a Sesquiterpene, Metabolite of Gibberella Fujikuroi,
NATIONAL RESEARCH COUNCIL OF CANADA HALIFAX (NOVA SCOTIA) ATLANTIC REGIONAL LAB
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A new sesquiterpene, cyclonerodiol with properties closely resembling those of the Gibberella metabolite was isolated from a species of Trichothesium. Direct comparison of samples infrared, proton magnetic resonance and mass spectra established that the two substances were identical. Cyclonerodiol was labeled with approximately the same efficiency as the kaurenolides when cultures were supplemented with potassium 2-14C DL-mevalonate. A scan of radioactivity after thinlayer chromatography of the neutral extract from such cultures showed one-fifth of the total radioactivity to be associated with the sesquiterpene.