Accession Number:

AD0730805

Title:

The Stimulation of Mitotic Activity in the Thymus and Bone Marrow of Rats by Kallikrein,

Descriptive Note:

Corporate Author:

NATIONAL RESEARCH COUNCIL OF CANADA OTTAWA (ONTARIO) DIV OF BIOLOGY

Personal Author(s):

Report Date:

1971-01-18

Pagination or Media Count:

7.0

Abstract:

A single intraperitoneal injection of a commercial preparation of kallikrein 3 or 5 units100 gm stimulated the mitotic actvity of cells in the thymus gland and the bone marrow of rats. This effect was observed three to six hours after injection as an increase in the mitotic index and the accumulation of cells in the metaphase stage of mitosis by the mitotic blocking agent, colcemid. Kallidrein did not affect the mitotic activity of isolated thymic lymphocytes. The release of mitogenically-active kinins is proposed as the means by which kallikrein enhances cell proliferation in vivo. Author

Subject Categories:

  • Anatomy and Physiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE