Accession Number:

AD0730795

Title:

Synthesis of New Antimalerial Drugs (9-Anthracenemethanols).

Descriptive Note:

Rept. no. 3 (Annual), 1 Apr 70-30 May 71,

Corporate Author:

INTERNATIONAL MINERALS AND CHEMICAL CORP LIBERTYVILLE ILL

Report Date:

1971-07-01

Pagination or Media Count:

37.0

Abstract:

The syntheses of three O-2-di-n-alkylamino-1-hydroxyethyl-10- haloanthracene hydrochlorides are described. Unsuccessful attempts were made to prepare the corresponding 3,6-dibromo-10-chloro-, 3,6-dibromo-, 3-trifluoromethyl-10-chloro-, 3,10-ditrifluoromethyl, and 3,10-dichloro- analogs. It was expected that all the substituted 9-anthraldehydes would react with dimethyl sulfonium methylide to form the desired substituted 9-anthrylethylene oxide intermediates. Unfortunately this reaction was only successful where the 9-anthraldehyde contained a 10 H, Br, or Cl. Data on the 10-chloro-dibutylamine derivative show this compound to be more active than either the corresponding unsubstituted compound or the halogenated 1- or 4-phenanthrene aminoalcohols synthesized previously. Author

Subject Categories:

  • Pharmacology
  • Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE