Comparative Study of Antimalarial and Other Drugs on G6PD Deficient Red Cells.
Final technical rept. Aug 70-Aug 71,
ISTITUTO DI EMATOLOGIA GENOA (ITALY)
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The studies concerning the effects of DFD on G6PD deficient red cells of the A- and B- variants were completed during the course of this contract. DFD is especially hemolytic even at low single dosages for G6PD deficient red cells of the B- type. The investigations on the new antimalarials WR 33063 1600 mg x day for 6 days and WR 30090 690 mg x day for 3-6 days demonstrated that these drugs were not hemolytic for G6PD deficient red cells B- type at the given dosages. Single dosages of Sulfalene Kelfizin were not hemolytic for G6PD deficient red cells transfused into normal recipients or to G6PD deficient volunteers. Author