Accession Number:
AD0730759
Title:
Comparative Study of Antimalarial and Other Drugs on G6PD Deficient Red Cells.
Descriptive Note:
Final technical rept. Aug 70-Aug 71,
Corporate Author:
ISTITUTO DI EMATOLOGIA GENOA (ITALY)
Personal Author(s):
Report Date:
1971-08-01
Pagination or Media Count:
42.0
Abstract:
The studies concerning the effects of DFD on G6PD deficient red cells of the A- and B- variants were completed during the course of this contract. DFD is especially hemolytic even at low single dosages for G6PD deficient red cells of the B- type. The investigations on the new antimalarials WR 33063 1600 mg x day for 6 days and WR 30090 690 mg x day for 3-6 days demonstrated that these drugs were not hemolytic for G6PD deficient red cells B- type at the given dosages. Single dosages of Sulfalene Kelfizin were not hemolytic for G6PD deficient red cells transfused into normal recipients or to G6PD deficient volunteers. Author
Descriptors:
Subject Categories:
- Pharmacology