Accession Number:

AD0730759

Title:

Comparative Study of Antimalarial and Other Drugs on G6PD Deficient Red Cells.

Descriptive Note:

Final technical rept. Aug 70-Aug 71,

Corporate Author:

ISTITUTO DI EMATOLOGIA GENOA (ITALY)

Report Date:

1971-08-01

Pagination or Media Count:

42.0

Abstract:

The studies concerning the effects of DFD on G6PD deficient red cells of the A- and B- variants were completed during the course of this contract. DFD is especially hemolytic even at low single dosages for G6PD deficient red cells of the B- type. The investigations on the new antimalarials WR 33063 1600 mg x day for 6 days and WR 30090 690 mg x day for 3-6 days demonstrated that these drugs were not hemolytic for G6PD deficient red cells B- type at the given dosages. Single dosages of Sulfalene Kelfizin were not hemolytic for G6PD deficient red cells transfused into normal recipients or to G6PD deficient volunteers. Author

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE