Morphologic Studies of Hepatitis.
Annual summary rept. 1 Sep 70-21 Sep 71,
MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
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Australia antigen was shown to contain DNA polymerase, which is probably RNA dependent. The morphologic change in viral hepatitis which best explained the clinical and laboratory abnormalities is damage of the endoplasmic reticulum. Halothane hepatitis, however, was characterized by mitochondrial injury, as well as by antimitochondrial antibodies and lymphocyte mitosis stimulated by halothane. Mitochondrial variations were also related to the state of thyroid function. The immunologic features of chronic hepatitis were related to morphologic changes, namely piecemeal necrosis. The economy of collagen metabolism was elucidated in relation to hepatic fibrosis. In cholestasis, hypertrophic hypoactive endoplasmic reticulum was found to be a result of loss of enzyme activity directed towards substrates bound to the lipid portion of microsomal cytochrome P-450. Author
- Medicine and Medical Research