Accession Number:

AD0730291

Title:

Effect of 90-Day Continuous Exposure to Methyliso-butylketone on Dogs, Monkeys and Rats

Descriptive Note:

Final rept. Jun-Sep 1970

Corporate Author:

SYSTEMED CORP NEWPORT BEACH CA

Report Date:

1971-06-01

Pagination or Media Count:

29.0

Abstract:

Continuous exposure of rats, dogs and monkeys to 410 mgcu M methylisobutylketone vapor MIBK was conducted to evaluate the provisional spacecraft exposure limit of 20 ppm established by the Space Science Board, NAS NRC in 1968. The exposure conducted in a simulated space cabin environment did not produce any measurable changes in dogs or monkeys. Rats developed hyaline droplet nephrosis within 2 weeks of exposure which was reversible upon removal from the MIBK even after 90 days. The data obtained indicated that the 60- minute emergency exposure limit of 100 ppm and the 90- and 1000-day provisional limits as established by the Space Science Board contain a wide margin of safety.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE