Immunologic Aspects of Beryllium Disease
Technical Report,01 Jan 1967,30 Jun 1969
CINCINNATI UNIV OH CINCINNATI
Pagination or Media Count:
The report reviews reasons that chronic beryllium disease CBD has been thought to have immunologic pathogenesis. It suggests how CBD fits the immunologic disease concept. CBD humoral factors study suggests antibody may be directed at gamma A, M, and G. Humoral transport of beryllium remains unclear. Immunoelectrophoresis and autoradiography of rat serum after Beryllium injections did not show any association of radioactivity with serum proteins. Culturing techniques for human, guinea pig and rabbit lymphocytes are described. Rabbit and guinea pig sensitizing methods are discussed. Rabbit lymphocytes are best for in vitro culturing but, as yet, have not bee stimulated by beryllium. This report describes an instance of successful passive transfer of beryllium hypersensitivity by local transfer of cells systemic transfer is less convincing. Pursuit of culture techniques with emphasis on in vitro diagnostic testing is recommended.
- Medicine and Medical Research
- Environmental Health and Safety