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Differences in Antigenic Specificity and Immunogenicity of Tissue Transplants.
Annual rept. no. 4, Mar 70-Mar 71,
CANCER INST TOKYO (JAPAN)
Pagination or Media Count:
Variant sublines cytologically different from their mother cell line were isolated when the cells were inoculated into the animals immunized with the same cell line, or when they were mixed with peritoneal lymphoid cells PLC which were previously sensitized with the same cell line used for the immunization. Antigenic specificity of these variant sublines was compared with that of their mother cell line by the technique of adoptive transfer test CCT tests in vivo as well as growth inhibition test in vitro by the sensitized PLC. Results showed that the PLC sensitized with either mother or variant cells, had a marked inhibitory effect on the growth of only corresponding cell line used for immunization. This suggested that the variant having an antigenic specificity different from their mother would be derived from their mother cell population under some, but specifically immunoselective condition of the hosts. Author
APPROVED FOR PUBLIC RELEASE