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Serum Enzymes in Experimental Ballistic Injury to Extremities.
Technical rept. Oct 69-Mar 71,
EDGEWOOD ARSENAL MD
Pagination or Media Count:
The activities of five serum enzymes in beagles with high-velocity gunshot extremity wounds were followed for 6 days after wounding. Creatine phosphokinase reflected the greatest sensitivity to muscle damage. Lactic dehydrogenase and serum alkaline phosphatase showed minimal increases. Debridement of wounds netted a return to normal enzyme values a day earlier than in wounds not treated. Complete debridement resulted in enzyme rises 35 to 75 less than the elevations observed in the nondebrided group. Otherwise, no difference could be recorded between the effects of partial or complete debridement upon the enzyme changes. The source of creatine phosphokinase, lactic dehydrogenase, glutamic-oxalacetic transaminase, and aldolase in the serum is the nonviable resected muscle as well as surrounding injured muscle. Secondary elevations of the activity of these enzymes are considered a result of damage to other organs or secondary damage to skeletal muscle. Author
APPROVED FOR PUBLIC RELEASE