Accession Number:

AD0729303

Title:

The Salivary Anti-A and Anti-B Isoantibody System in Group O Males.

Descriptive Note:

Progress rept.,

Corporate Author:

ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Report Date:

1971-04-20

Pagination or Media Count:

20.0

Abstract:

The incidence of anti-A and anti-B saliva agglutinins in group O males, the response of these agglutinins to parenteral immunization with A and B blood group substances, and the immunoglobulins responsible for this response were studied. In addition, the relationship of saliva agglutinin titers to titers of anti-A and anti-B antibodies in the corresponding sera was examined. Anti-A whole saliva agglutinins were detected in 98 percent and anti-B in 96 percent of 80 group O males. After subcutaneous injection of five group O males with A and B blood group substances, whole saliva anti-A agglutinins increased significantly in two individuals and anti-B in four, and parotid saliva anti-A agglutinins in one and anti-B in three. Both whole and parotid saliva agglutinating activity were demonstrated to be primarily due to secretory IgA, both pre- and postimmunization. IgG coating activity was also demonstrated in postimmunization whole saliva. In 80 group O males, whole saliva agglutinin titers of individuals with high-titer serum antibodies saline agglutinins, neutralization-resistant antibodies, and hemolysins were usually not insignificantly different from aliva titers of individuals with low-titer serum antibodies. Author

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE