The Salivary Anti-A and Anti-B Isoantibody System in Group O Males.
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
Pagination or Media Count:
The incidence of anti-A and anti-B saliva agglutinins in group O males, the response of these agglutinins to parenteral immunization with A and B blood group substances, and the immunoglobulins responsible for this response were studied. In addition, the relationship of saliva agglutinin titers to titers of anti-A and anti-B antibodies in the corresponding sera was examined. Anti-A whole saliva agglutinins were detected in 98 percent and anti-B in 96 percent of 80 group O males. After subcutaneous injection of five group O males with A and B blood group substances, whole saliva anti-A agglutinins increased significantly in two individuals and anti-B in four, and parotid saliva anti-A agglutinins in one and anti-B in three. Both whole and parotid saliva agglutinating activity were demonstrated to be primarily due to secretory IgA, both pre- and postimmunization. IgG coating activity was also demonstrated in postimmunization whole saliva. In 80 group O males, whole saliva agglutinin titers of individuals with high-titer serum antibodies saline agglutinins, neutralization-resistant antibodies, and hemolysins were usually not insignificantly different from aliva titers of individuals with low-titer serum antibodies. Author
- Anatomy and Physiology