Accession Number:

AD0728856

Title:

High-Resolution Autoradiography of Malarial Parasites Treated with Chloroquine.

Descriptive Note:

Annual rept. no. 2,

Corporate Author:

CASE WESTERN RESERVE UNIV CLEVELAND OHIO INST OF PATHOLOGY

Personal Author(s):

Report Date:

1971-09-01

Pagination or Media Count:

19.0

Abstract:

Electron microscope autoradiography was performed on the erythrocytic stages of the rodent malarial parasite, Plasmodium berghei, after exposure to 3H-chloroquine. 3H-chloroquine becomes selectively localized within the parasite food vacuoles one hour after the drug administration, and remains in this structure up to 24 hours. This study indicated the food vacuoles as the primary site of chloroquine concentration within the parasite. Author

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE