Accession Number:

AD0728790

Title:

Effects of Endotoxin on Myocardial Hemodynamics, Performance and Metabolism during Beta Adrenergic Blockade

Descriptive Note:

Technical rept.

Corporate Author:

OKLAHOMA UNIV MEDICAL CENTER OKLAHOMA CITY

Personal Author(s):

• Hinshaw, Lerner B.
• Greenfield, L. J.
• Archer, L. T.
• Guenter, C. A.

Report Date:

1971-08-02

Pagination or Media Count:

23.0

Abstract:

The question of the precise role of the heart in shock has been largely unresolved. Previous separate reports have shown that both excitatory and depressant actions on the myocardium after endotoxin are observed. The purpose of the present study was to assay the possibility of a direct myocardial toxic action of endotoxin or a circulating myocardial depressant factor released in the blood of endotoxin shocked animals. This was accomplished by utilization of beta adrenergic blockade propranolol under the experimental conditions of constant cardiac output and aortic pressure in an isolated canine heart preparation exchanging blood with an intact support animal shocked by endotoxin.

Descriptors:

• *SEPTICEMIA
• *SHOCK(PATHOLOGY)
• EXPERIMENTAL DATA
• BACTERIA
• TOXICITY
• BLOOD CIRCULATION
• BLOOD PRESSURE
• SYMPATHOLYTIC AGENTS
• AUTONOMIC NERVOUS SYSTEM
• TOXINS AND ANTITOXINS
• CARDIOVASCULAR SYSTEM
• METABOLISM
• PHYSIOLOGY

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE