A Comparison of the Response of Canine and Primate Species to Bacterial and Bacterial Endotoxin
OKLAHOMA UNIV MEDICAL CENTER OKLAHOMA CITY
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The major purpose of this report is to review findings from our laboratory comparing the actions of intravenously administered live E. coli organisms and E. coli endotoxin in dogs and monkeys. The preponderance of data obtained from such experiments seems to indicate that the endotoxin shock model is a valid means of eliciting many of the characterisitcs of shock seen in the patient. Differences are apparent between the models, however, and further research is therefore needed to perfect a more adequate experimental preparation.
- Medicine and Medical Research