Studies of the Effect of Personality on Reactivity to LSD
Technical rept. for 1962-1966
EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD
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Case records of 52 Army volunteers given from 1.1 to 2.0 micrograms kg of LSD orally between 1962 and 1966 were studied. Since 1966 no further studies have been performed. Significant relationships were found between personality as measured by the Minnesota Multiphasic Personality Inventory and Army General Intelligence Test and performance following administration of LSD. Resistant subjects at lower doses were found to be more intelligent, energetic, and outgoing. Sensitive subjects were less intelligent, constricted, more anxious, over-controlled, and dependent. At the higher doses the picture was not as clear, but personality factors were still highly correlated with performance. The Pa paranoia scale had a higher correlation with performance than did dose. The K positive test-taking attitude, Hs hypochondriasis, and Si social introversion scales were positively correlated with performance at lower doses and negatively correlated with performance at higher doses.