Accession Number:

AD0726973

Title:

Chemotherapy of Rodent Malaria Drug Action Against Exo-Erythrocytic Stages and Drug Rsistant Strains.

Descriptive Note:

Final technical rept. 1 May 70-30 Apr 71,

Corporate Author:

LIVERPOOL SCHOOL OF TROPICAL MEDICINE (ENGLAND) DEPT OF PARASITOLOGY

Personal Author(s):

Report Date:

1971-04-01

Pagination or Media Count:

36.0

Abstract:

Evaluation of seven older and seven newer WRAIR compounds as blood schizontocides was completed and a further five are continuing. Causal prophylactic and sporontocidal investigations were blocked by a zoonosis in the mosquito colony. Drug interaction has been further investigated and earlier evidence of potentiation between menoctone and cycloquanil is confirmed. Investigations on the mode of action of chloroquine and mechanisms of drug resistance confirm earlier hypothesis of a respiratory switch mechanism and suggest a simple physico-chemical explanation of drug uptake. Chloroquine-resistant parasites are shown to possess a satellite DNA. Author

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE