Effects of Injected Histamine on Intracranial Pressure and Systemic Blood Pressure.
Rept. for Mar-May 70,
SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX
Pagination or Media Count:
To measure intracranial and systemic arterial pressures, ten Macaca mulatta monkeys were surgically prepared with catheters in the subdural space and in the abdominal aorta via the femoral artery. The monkeys were stabilized in a state of light surgical anesthesia, then administered 50 microgramskg. of histamine intravenously over a 30-second injection period. ICP and blood pressure were monitored for 30 minutes. ICP reached a maximum pressure of 165 of baseline value at 2 minutes post-injection and was down to 110 of baseline at the end of the 30-minute observation period. Blood pressure reached the nadir of 72 of baseline at 4 minutes postinjection, and at the end of 30 minutes the pressure had returned to 102 of baseline value. Author
- Anatomy and Physiology