An Experimental Model for the Study of Infectious Otitis Externa.
BRIGHAM YOUNG UNIV PROVO UTAH DEPT OF MICROBIOLOGY
Pagination or Media Count:
Through study of five small laboratory animals the guinea pig was found to be a useful experimental model for the study of otitis externa. Infection of the external ear canal could be induced by methods which would result in human disease. The clinical appearance of the diseased ear canal was similar to that in man. Prolonged exposure to water resulted in a shift from the normal gram positive bacterial flora to abnormal gram negative flora and in disease. Data presented suggests that the presence of a normal bacterial flora is of significance in reducing the incidence of otitis externa. Removal of ear canal lipids did not result in disease although this procedure predisposed the ear to infection following contamination by Pseudomanas aeruginosa. The data supports the concept of a multiplex etiology of otitis externa. Author
- Medicine and Medical Research