Some Views on the Pathogenesis of Inflammation,
SAINT BARTHOLOMEW'S HOSPITAL MEDICAL COLL LONDON (ENGLAND) DEPT OF PATHOLOGY
Pagination or Media Count:
The purpose of the study was to investigate the role of polymorphonuclear leucocytes in the acute inflammatory response. These cells are known to contain high concentrations of lysosomal enzymes and kinin-forming enzymes, and it has been suggested that they are warehouses for these important mediators. The second aspect considered was the source and origins of the mononuclear cells that make up the chronic inflammatory lesion. The monocytic origin of macrophages seems well-established, although some still claim the participation of the small lymphocytes. In the experiments described, the respective roles of bone-marrow and lymph nodes as sources of cells in chronic inflammation have been investigated.
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