Distribution of Carboxyhaemoglobin in Human Erythrocytes Following Inhalation of Carbon Monoxide,
FLYING PERSONNEL RESEARCH COMMITTEE LONDON (ENGLAND)
Pagination or Media Count:
The distribution of carbon monoxide in erythrocytes of persons exposed to high concentrations of gas for short periods was investigated using a modification of the staining technique described by Betke and Kleihauer. The experiments consisted of examination of citrated human blood carboxylated with pure CO and then decarboxylated with oxygen, and capillary blood taken at intervals following inhalation of CO as the pure gas or from tobacco smoke. The observations suggest that 1 following inhalation of CO only the erythrocytes exposed to the gas in the lungs are carboxylated 2 redistribution of the carboxyhaemoglobin between erythrocytes during subsequent circulation does not occur 3 the hypoxic insult to an individual erythrocyte will not be related to the carboxyhaemoglobin saturation as determined on whole blood.
- Anatomy and Physiology