Final Scientific Report.
CHICAGO UNIV ILL DEPT OF BIOLOGY
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The research was concerned with the nature of pathogenicity for infectious agents, emphasizing bacterial systems. Phytopathogenic bacterial species were utilized for model systems to avoid the immunological aspects of susceptibility and resistance. The program was concerned with the biochemical and enzymological aspects of pathogenicity. Initial efforts were devoted to the nutritional characteristics of the pathogen with respect to the availability of required nutrilites in the host-environment. The results clearly indicated that nutritional requirements of the pathogen had to be satisfied at the site of inoculation or of localization for the pathogen to be virulent. The outcome of this program resulted in the formulation of the nutrition-inhibition hypothesis of pathogenicity which includes such concepts as the induction of extracellular enzymes by small molecules in the host-environment and of inhibitory compounds produced in the host in response to the metabolism of the invading pathogen.
- Medicine and Medical Research