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Leptospiral Ultrasonic Polyvalent Depot-Vaccine (Leptsspkrsznaya Ultrazeiuksvaya Pslieyalentnaya Depo-Vakchina),
ARMY FOREIGN SCIENCE AND TECHNOLOGY CENTER CHARLOTTESVILLE VA
Pagination or Media Count:
A new polyvalent leptospiral depot-vaccine prepared by the method of ultrasonic destruction of a concentrated suspension of leptospira with subsequent standardization and deposition with aluminum hydroxide was evaluated. The vaccine contains antigens isolated from 5 serotypes of leptospirae grippotyphosa, hebdomadis, canicola, pomona and tarassovi and protects from infection with 8 types of leptospira infection grippotyphosa, hebdomadis, saxkoebing, canicola, icterohaemorrhagiae A and AB, pomona and tarassovi. After a single immunization in a dose of 1.5 ml rabbits remained immune for 1 year. Single vaccination with a crude vaccine protected rabbits from infection with a virulent culture in a dose of 4-15 D1m. Author
APPROVED FOR PUBLIC RELEASE