Humoral Antibody Responses in Newborn Monkeys after Mixed Gamma-Neutron Irradiation.
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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Newborn monkeys exposed to 200 rads of mixed gamma-neutron radiation and subsequently injected with bovine serum albumin BSA, incorporated in saline, produced antibody titers that were significantly higher than those observed in the corresponding nonirradiated controls p0.05. The titers of irradiated animals injected with BSA incorporated in adjuvant incomplete Freund type while higher than those of the nonirradiated controls were not significantly different. Irradiated monkeys receiving BSA in adjuvant and neoplastic tissue simultaneously exhibited significantly lower titers than those monkeys which were administered neoplastic tissues 4 or more days after BSA injections. The enhanced antibody responses seen in the newborn monkey are viewed as unusual responses while the depressed responses are recognized as more typical. Positive explanations for both responses are discussed. Author
- Anatomy and Physiology