Human 'Vibrio Cholerae' A Histologic Review of 117 Cases in the Philippines
NAVAL MEDICAL RESEARCH UNIT NO 2 MANILA(PHILIPPINES)
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Analysis of 117 Asiatic cholera patients, of which 81 or 69 were infants and children, revealed a multiplicity of cholera-induced histopathology secondary to shock, electrolyte imbalance, and cholera toxins. In a majority of cases the proximate cause of death was ascribable to acute tubular nephrosis. Visceral hemorrhage was thought a consequence of damage to capillary endothelium form cholera toxins. Hypokalemic cardiomyopathy, characterized by cytoplasmic vacuolation, hyalinization, and overcontraction of myofibrils, was a predominant feature. Focal inflammatory myocytolysis and an increase in Anitschkow myocytes constituted evidence of the toxicity of the vibrio involving the myocardium. Pulmonary congestion, and on occasion haemorrhage, interstitial pneumonia, and focal collapse were observed. A high incidence of fatty change of the liver in cholera victims of the younger age group suggested malnutrition might have been a predisposing factor which contributed to susceptibility and mortality.
- Medicine and Medical Research