Factors That Influence Viral Parasitism.
NEW YORK STATE VETERINARY COLL ITHACA VETERINARY VIRUS RESEARCH INST
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A new concept for prevention of disease was developed after finding that bovine virus diarrhea BVD virus protected pigs against hog cholera HC, measles virus from human beings protected dogs against distemper, and human adenovirus adenovirus type 4 virus protected dogs against infectious canine hepatitis canine adenovirus type 1. A model first was developed to study the protection between heterotypically related viruses. Because HC virus was host specific and invariably lethal, and BVD virus prevented death in pigs, this heterotypic pair gave unequivocal results. Some features of this heterotypic system are a BVD and HC viruses did not cross neutralize b BVD and HC viruses cross fixed complement c a prior inoculation of BVD accelerated subsequent production of antibody to HC virus when the two viruses were sequentially inoculated d the type antibody associated with this secondary response was Igg. Heterotypically related virus protected by completing the first of 2 stages in development of antibody. With the first stage already completed, antibody appeared earlier consequently, virus growth was restricted and the effects of virus eliminated. Antigenic analysis of BVD virus showed soluble antigen fixed complement and protected pigs against HC. It appeared that the soluble antigen component was responsible for the heterotypic relationship. Author
- Animal Husbandry and Veterinary Medicine