The Effect of Chronic Hypercapnia on Oxygen Affinity and 2, 3 Diphosphoglycerate as Related to Submarine Exposure
NAVAL SUBMARINE MEDICAL RESEARCH LAB GROTON CT
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The relationship between oxygen affinity and 2,3 diphosphoglycerate 2,3 DPG in the red cell has been studied in chronic hypercapnia induced by prolonged exposure of guinea pigs to 15 CO2 in 21 O2. Red cell pH fell to a minimum after six hours of exposure and subsequently rose without reaching initial values after seven days of exposure. Both oxygen half-saturation pressure P50 and the level of 2,3 DPG of the red cells followed the time course of the pH changes. However, both parameters required 24 hours to reach a minimum, following which they increased steadily and were not different from control values after seven days of exposure.
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