Accession Number:

AD0720808

Title:

Effects of Monoamine Oxidase Inhibitors and Reserpine on Brain Amines in Altitude-Exposed Rats.

Descriptive Note:

Interim rept. Nov 69-Jan 70,

Corporate Author:

SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s):

Report Date:

1971-02-01

Pagination or Media Count:

11.0

Abstract:

Groups of rats were injected with either pargyline, Parnate, Catron, or reserpine 75 mg.kg., 5 mg.kg., 5 mg.kg., and 5 mg.kg. respectively and taken to a simulated altitude of 18,500 ft. The expected rise in the brain monoamine norepinephrine and serotonin levels after administration of monoamine oxidase inhibitors and the decrease of norepinephrine by reserpine were attenuated by altitude exposure. In another experiment, 100 percent oxygen was substituted for ambient air. In this case, the attenuation of monoamine elevations by the inhibitors was reversed. However, the added oxygen did not reverse the attenuation of the norepinephrine decrease by reserpine. Author

Subject Categories:

  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE