Accession Number:

AD0720304

Title:

Research in Intravascular Coagulation at Karolinska Institute, Stockholm, Sweden,

Descriptive Note:

Corporate Author:

OFFICE OF NAVAL RESEARCH LONDON (ENGLAND)

Personal Author(s):

Report Date:

1970-12-04

Pagination or Media Count:

7.0

Abstract:

One of the primary research interests in the Thoracic Clinic of the Karolinska Institute is the hemodynamic changes occurring in the state of DIC. In investigating the mechanisms by which intravascular clotting affects vascular tone and tissue perfusion, it was found that platelets released vasoactive adenine nucleotides during thrombin infusion into defibrinogenated dogs. These nucleotides then caused vasodilatation and decreased vascular resistance. Defibrinogenation has also been shown to prevent clotting after surgical manipulation of veins or insertion of prosthetic venous grafts. Author

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE