Accession Number:

AD0720281

Title:

The Effect of d-LSD-25 and Related Compounds on the Subcortical Electrograms

Descriptive Note:

Progress Report

Corporate Author:

TULANE UNIV NEW ORLEANS LA SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

1959-01-20

Pagination or Media Count:

6.0

Abstract:

One phase of the project was to test the effect of d-LSD-25 and related compounds on the subcortical electrograms to see whether there could be demonstrated correlations between paroxysmal hypersynchronous activity in the septal andor hippocampal region and known psychotomimetic effect. A second phase of this study was to test the effect of serotonin on the animal by giving a monoamineoxidase inhibitor phenylisopropylhydrosine combined with a serotonin precursor 5-hydroxytryptophane which crosses the blood brain barrier. Three studies were also done giving animals EA-1476 in doses ranging from 125 to 500 gamma per kilo.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE