Accession Number:

AD0719998

Title:

Separation of Polythiadioxopiperazine Antibiotics by Thin-Layer Chromatography,

Descriptive Note:

Corporate Author:

NATIONAL RESEARCH COUNCIL OF CANADA HALIFAX (NOVA SCOTIA) ATLANTIC REGIONAL LAB

Personal Author(s):

• Rahman,R.
• Safe,S.
• Taylor,A.

Report Date:

1970-08-28

Pagination or Media Count:

4.0

Abstract:

In recent years the number of 2,5-epipolythia-3,6-dioxopiperazine antibiotics has increased significantly due to isolation of new members of the series and by chemical transformations of the naturally-occurring compounds. By extensive chemical andor X-ray crystallographic investigations the structure of gliotoxin I, sporidesmin II, X 2, R OH and dehydrogliotoxin III, X 2 was determined and other closely related compounds have since been isolated or synthesized. The report deals with the thin-layer chromatographic behavior of fifteen of these sulfur-containing compounds. The separation of polysulfides II, X 1, 2, 3, 4, R OH and III, X 1, 2, 3, 4 differing only in the number of sulfur atoms in the 2,5 bridge is particularly noted. Author

Descriptors:

• (*ANTIBIOTICS
• *THIN LAYER CHROMATOGRAPHY)
• (*NITROGEN HETEROCYCLIC COMPOUNDS
• THIN LAYER CHROMATOGRAPHY)
• SULFUR HETEROCYCLIC COMPOUNDS
• POLYCYCLIC COMPOUNDS
• INDOLES
• KETONES
• CANADA

Subject Categories:

• Pharmacology
• Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE