Accession Number:
AD0719998
Title:
Separation of Polythiadioxopiperazine Antibiotics by Thin-Layer Chromatography,
Descriptive Note:
Corporate Author:
NATIONAL RESEARCH COUNCIL OF CANADA HALIFAX (NOVA SCOTIA) ATLANTIC REGIONAL LAB
Report Date:
1970-08-28
Pagination or Media Count:
4.0
Abstract:
In recent years the number of 2,5-epipolythia-3,6-dioxopiperazine antibiotics has increased significantly due to isolation of new members of the series and by chemical transformations of the naturally-occurring compounds. By extensive chemical andor X-ray crystallographic investigations the structure of gliotoxin I, sporidesmin II, X 2, R OH and dehydrogliotoxin III, X 2 was determined and other closely related compounds have since been isolated or synthesized. The report deals with the thin-layer chromatographic behavior of fifteen of these sulfur-containing compounds. The separation of polysulfides II, X 1, 2, 3, 4, R OH and III, X 1, 2, 3, 4 differing only in the number of sulfur atoms in the 2,5 bridge is particularly noted. Author
Descriptors:
Subject Categories:
- Pharmacology
- Organic Chemistry