Correlation of Pooling and Resistance Changes in the Canine Forelimb in Septic Shock
OKLAHOMA UNIV MEDICAL CENTER OKLAHOMA CITY
Pagination or Media Count:
A major problem in endotoxin shock is the role of peripheral pooling of blood in the development of the irreversible state. The present study was designed to determine if there was a causal relationship between pre- and post- capillary resistance changes in the canine forelimb and later peripheral pooling. Experiments were carried out on innervated and denervated forelimbs perfused by anesthetized animals administered lethal injections of live E. coli organisms or endotoxin. Absence of pooling in the forelimb was consistently noted and perfusate was continuously yielded from the limb into the venous effluent, even in the presence of a decreased pre- to post-capillary resistance ratio. Animals were observed to die with shrunken limb volumes presumably resulting from decreased perfusion pressure and active pre-capillary constriction. Severely depressed flow rates and distending pressures produced increases in small vessel and venous segment resistances on a passive basis. Results offer no evidence that loss of circulating blood into skin and muscle may account for the development of systemic hypotension in experimental septic shock.
- Medicine and Medical Research