DECREASED DIURESIS IN RESPONSE TO A THIAZIDE DIURETIC AT A SIMULATED ALTITUDE.
Interim rept. for Jan-Mar 70,
SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX
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The effect of hydrochlorothiazide on the diuretic response of rats at 12,000 ft. was examined. After administration of a saline load, with and without drug, urine was collected over a 5-hr. period at both altitude and ground level. Total volume, urinary Na and K, and pH were determined. The most pronounced effect of the altitude-drug interaction was decrease in the expected urine volume while the increased Na output did not change from the observed with the drug at ground level. The results are discussed in relation to the possible basis for the observed phenomenon. Author
- Stress Physiology